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Learn more about SOLIQUA 100/33

Whether you are considering SOLIQUA 100/33 or already have a prescription, here are some frequently asked questions and answers to help you learn more.

How do you pronounce SOLIQUA 100/33?

SOLIQUA 100/33 is pronounced phonetically as "So-lee-kwa hundred thirty-three".

What is SOLIQUA 100/33?

SOLIQUA 100/33 is an injectable prescription medicine that contains 2 diabetes medicines, insulin glargine and lixisenatide, that may improve blood sugar (glucose) control in adults with type 2 diabetes, when used with diet and exercise in people who are not controlled with long-acting (basal) insulin (less than 60 units daily) or lixisenatide.

  • It has not been studied in people with a history of pancreatitis.
  • It is not recommended for people who also take lixisenatide or other medicines called GLP-1 receptor agonists.
  • It is not for use in people with type 1 diabetes, diabetic ketoacidosis, or who have a stomach problem that causes slow emptying (gastroparesis).
  • It has not been studied together with short-acting insulin.
  • It is not known if SOLIQUA 100/33 is safe and effective in children under 18 years of age.
What are the two medicines in SOLIQUA 100/33?

SOLIQUA 100/33 combines two diabetes medicines that
work to lower blood sugar levels:

Lantus® (insulin glargine 100 Units/mL) – a long-acting insulin
Adlyxin™ (lixisenatide 33 mcg/mL) – a glucagon-like peptide receptor agonist (GLP-1 RA) that starts working after you eat a meal

What does 100/33 represent in the name SOLIQUA 100/33?
It represents the insulin glargine and lixisenatide in the medicine. Each milliliter (mL) of SOLIQUA 100/33 contains 100 units of insulin glargine and 33 micrograms (mcg) of lixisenatide.
What is Insulin?

Insulin is a hormone produced by the pancreas that helps your body use or store the sugar you get from food.

Here’s how it works: Your blood sugar levels rise after eating, and that signals the pancreas to release insulin.  The pancreas normally releases enough insulin to help your body absorb the sugar out of the bloodstream and then either uses the sugar for energy or stores it.

In people with type 2 diabetes, the pancreas does not produce enough insulin or the body can’t properly use the insulin it produces to keep their blood sugar levels within a normal range. That is why, if you have type 2 diabetes, your doctor may prescribe a diabetes medicine that contains insulin.

What is glucagon-like peptide (GLP-1)?

GLP-1 is a hormone that is secreted from your small intestine when you eat. It helps control your blood sugar levels in several ways:

  • Helps the body produce more insulin.
  • Helps slow down the process by which the liver releases sugar into the bloodstream.
  • Slows the rate at which food moves from your stomach into the intestine.

People with type 2 diabetes may be prescribed a GLP-1 RA to help manage sugar spikes after a meal.

What are the most common side effects of SOLIQUA 100/33?

The most common side effects of SOLIQUA 100/33 may include low blood sugar (hypoglycemia), nausea, headache, stuffy or runny nose and sore throat, allergic reactions, diarrhea and upper respiratory tract infection.

Nausea and diarrhea usually happen more often when you start using SOLIQUA 100/33.

How is SOLIQUA 100/33 administered?

SOLIQUA 100/33 is administered using a prefilled, disposable SoloStar® pen.

Each pen contains 300 units of medicine. You should only inject SOLIQUA 100/33 once-daily with a dose range of 15 to 60 units. Your doctor will prescribe the right dose for you.

See step-by-step instructions on how to use the SOLIQUA 100/33 pen.

How often do I use SOLIQUA 100/33?

You should inject your dose within one hour before your first meal of the day, preferably at the same time each day. 

Will my dose for SOLIQUA 100/33 change over time?

Your dose may change depending on your blood sugar levels.

When you begin treatment with SOLIQUA 100/33, your doctor will set your blood sugar goal and advise you on how often you should check your blood sugar levels. If your blood sugar levels change, your doctor may adjust your dose.

Do not make any changes to your SOLIQUA 100/33 dose or any other treatments without first talking to your doctor.

Monitoring your blood sugar can help you and your doctor understand the status of your type 2 diabetes and how well your diabetes management plan, including diet and exercise, is working.

Download our Blood Sugar Tracker to help you keep track of your blood sugar levels.

What if I miss a dose?

If you miss a dose, skip the dose and continue as prescribed on the next day. You should never administer two doses on the same day or increase the dose to make up a missed dose.

Is there a savings program for SOLIQUA 100/33? 

Yes. With the SOLIQUA 100/33 Savings Card, you may be eligible for a $0 CO-PAY for the next 12 months. Restrictions apply.*

Find out if you’re eligible for a SOLIQUA 100/33 $0 CO-PAY and download your Savings Card now.

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Get your SOLIQUA 100/33 Savings Card now. See if you're eligible for a $0 CO-PAY for the next 12 months. Restrictions apply.*


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Considering SOLIQUA 100/33? Find out more, plus learn about blood sugar management.

Questions to Ask Your Doctor

Learn what to ask about SOLIQUA 100/33 and overall diabetes management.