Effective April 1, 2018:
*Severe symptomatic hypoglycemia defined as an event requiring assistance of another person to actively administer carbohydrate, glucagon, or other resuscitative actions.
†Documented symptomatic hypoglycemia defined as an event with typical symptoms of hypoglycemia accompanied by a self-monitored plasma glucose value equal to or less than 70 mg/dL.
‡Gastrointestinal adverse reactions occur more frequently at the beginning of therapy.
DISCONTINUATION DUE TO GASTROINTESTINAL EVENTS IN CLINICAL TRIALS: 1.1%2